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β-Cyclodextrin: a green supramolecular catalyst assisted eco-friendly one-pot three-component synthesis of biologically active substituted pyrrolidine-2-one† † Electronic supplementary information (ESI) available: All of the experimental details and the spectroscopic details, i.e., spectroscopic data and all the scanned copies of 1H, 13C &19F NMR spectra of the synthesised derivatives. See DOI: https://doi.org/10.1039/d2ra08054k

ABSTRACT: A green, novel and eco-efficient synthetic route towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular solid as a green and eco-benign catalyst at room temperature under water–ethanol solvent medium. The exploration of the green catalyst β-cyclodextrin for the metal-free one-pot three-component synthesis of a wide range of highly functionalized bio-active heterocyclic pyrrolidine-2-one moieties from easily available aldehydes and amines explains the superiority and uniqueness of this protocol. An eco-efficient protocol towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular catalyst at room temperature under water–ethanol solvent medium.

SUBMITTER: Paul S

PROVIDER: S-EPMC9924053 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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