Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective.

ABSTRACT: Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be challenging in post transplantation management. The introduction of calcineurin inhibitors dramatically improved recipients' short-term prognosis. However, long-term clinical outlook remains poor, moreover, the lifelong dependency on these toxic drugs leads to chronic deterioration of graft function, in particular the renal function, infections and de-novo malignancies. These observations led investigators to identify alternative therapeutic options to promote long-term graft survival, which could be used concomitantly, but preferably, replace pharmacologic immunosuppression as standard of care. Adoptive T cell (ATC) therapy has evolved as one of the most promising approaches in regenerati

SUBMITTER: Amini L 

PROVIDER: S-EPMC9924129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature