Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.

ABSTRACT:

Background

Variation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is a compelling candidate source of craniofacial morphological variation. We performed a detailed morphometric analysis of an allelic series of E14.5 Ephb1-3 receptor mutants to determine the effect of each paralogous receptor gene on craniofacial morphology.

Results

We found that Ephb1, Ephb2, and Ephb3 genotypes significantly influenced facial shape, but Ephb1 effects were weaker than Ephb2 and Ephb3 effects. Ephb2^-/- and Ephb3^-/- mutations affected similar aspects of facial morphology, but Ephb3^-/- mutants had additional facial shape effec

SUBMITTER: Mincer ST 

PROVIDER: S-EPMC9924224 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature