Protective effects and mechanisms of Lizhong decoction against non-alcoholic fatty liver disease in a rat model.

ABSTRACT:

Objective

To investigate the protective effects and molecular mechanisms of Lizhong decoction (, LZD) against non-alcoholic fatty liver disease (NAFLD).

Methods

Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD, and were administered LZD by gavage for four weeks. Potential therapeutic targets for NAFLD were analyzed using network pharmacology. Liver pathology was evaluated using Oil Red O and hematoxylin-eosin staining. Furthermore, mitochondrial function, lipid metabolism, oxidative stress, and inflammatory response were examined.

Results

Rats with NAFLD exhibited high levels of hepatic damage and cholesterol deposition. Moreover, apoptosis was increased, superoxide dismutase and glutathione content were reduced, malondialdehyde content was inc

SUBMITTER: Jiayao Y 

PROVIDER: S-EPMC9924662 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature