Efficacy of active ingredients in Qingdai on ulcerative colitis: a network pharmacology-based evaluation.

ABSTRACT:

Objective

To elucidate the protective effect of Qingdai (, QD) on ulcerative colitis (UC) by means of and approaches.

Methods

A systems pharmacology analysis was per-formed to predict the active components of QD whereas the putative biological targets of QD against UC were obtained through target fishing, network cons-truction and enrichment analyses. Meanwhile, we examined the ameliorative effect of QD in a mouse model of dextran sulfate sodium (DSS)-induced colitis. During the 10-day experiment, the control and diseased mice were given with oral gavages of QD (1.3 g raw herbs·kg·d) or 5-aminosalicylic acid (5-ASA, 100 mg·kg·d) every day. The underlying pharma-cological mechanisms of QD in UC were determined using polymerase chain reaction tests, histological staining, enzy

SUBMITTER: Yue LI 

PROVIDER: S-EPMC9924692 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature