ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease.

ABSTRACT: Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitive type. In this work, we used attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy to analyze plasma samples for discriminating MS patients from healthy control individuals, and identifying potential spectral biomarkers helping the diagnosis through a quick non-invasive blood test. The cohort of the study consists of 85 subjects, including 45 MS patients and 40 healthy controls. The differences in the spectral features both in the fingerprint region (1800-900 cm^-1) and in the high region (3050-2800 cm^-1) of the infrared spectra were highlighted also with the support of different chemometric methods, to capture t

SUBMITTER: Crocco MC 

PROVIDER: S-EPMC9924868 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature