Identification of tumor antigens and immune subtypes of acute myeloid leukemia for mRNA vaccine development.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy, and there has not been any significant improvement in therapy of AML over the past several decades. The mRNA vaccines have become a promising strategy against multiple cancers, however, its application on AML remains undefined. In this study, we aimed to identify novel antigens for developing mRNA vaccines against AML and explore the immune landscape of AML to select appropriate patients for vaccination.

Methods

Genomic data and gene mutation data were retrieved from TCGA, GEO and cBioPortal, respectively. GEPIA2 was used to analyze differentially expressed genes. The single cell RNA-seq database Tumor Immune Single-cell Hub (TISCH) was used to explore the association between the potenti

SUBMITTER: Wang F 

PROVIDER: S-EPMC9924891 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature