Disentangling the effects of Alzheimer's and small vessel disease on white matter fibre tracts.

ABSTRACT: Alzheimer's disease and cerebral small vessel disease are the two leading causes of cognitive decline and dementia and coexist in most memory clinic patients. White matter damage as assessed by diffusion MRI is a key feature in both Alzheimer's and cerebral small vessel disease. However, disease-specific biomarkers of white matter alterations are missing. Recent advances in diffusion MRI operating on the fixel level (fibre population within a voxel) promise to advance our understanding of disease-related white matter alterations. Fixel-based analysis allows derivation of measures of both white matter microstructure, measured by fibre density, and macrostructure, measured by fibre-bundle cross-section. Here, we evaluated the capacity of these state-of-the-art fixel metrics to disentangle th

SUBMITTER: Dewenter A 

PROVIDER: S-EPMC9924910 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature