Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.

ABSTRACT: Cerebral white matter hyperintensities on MRI are markers of cerebral small vessel disease, a major risk factor for dementia and stroke. Despite the successful identification of multiple genetic variants associated with this highly heritable condition, its genetic architecture remains incompletely understood. More specifically, the role of DNA methylation has received little attention. We investigated the association between white matter hyperintensity burden and DNA methylation in blood at ∼450 000 cytosine-phosphate-guanine (CpG) sites in 9732 middle-aged to older adults from 14 community-based studies. Single CpG and region-based association analyses were carried out. Functional annotation and integrative cross-omics analyses were performed to identify novel genes underlying the relatio

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9924914 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature