Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity.

ABSTRACT: Mutations that extend lifespan are associated with enhanced resistance to stress. To better understand the molecular mechanisms underlying this relationship, we directly compared lifespan extension, resistance to external stressors, and gene expression in a panel of nine long-lived Caenorhabditis elegans mutants from different pathways of lifespan extension. All of the examined long-lived mutants exhibited increased resistance to one or more types of stress. Resistance to each of the examined types of stress had a significant, positive correlation with lifespan, with bacterial pathogen resistance showing the strongest relationship. Analysis of transcriptional changes indicated that all of the examined long-lived mutants showed a significant upregulation of multiple stress response pathways

SUBMITTER: Soo SK 

PROVIDER: S-EPMC9924947 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature