WMDS.net: a network control framework for identifying key players in transcriptome programs.

ABSTRACT:

Motivation

Mammalian cells can be transcriptionally reprogramed to other cellular phenotypes. Controllability of such complex transitions in transcriptional networks underlying cellular phenotypes is an inherent biological characteristic. This network controllability can be interpreted by operating a few key regulators to guide the transcriptional program from one state to another. Finding the key regulators in the transcriptional program can provide key insights into the network state transition underlying cellular phenotypes.

Results

To address this challenge, here, we proposed to identify the key regulators in the transcriptional co-expression network as a minimum dominating set (MDS) of driver nodes that can fully control the network state transition. Based on the theory

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9925106 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature