Primary prevention of acute cardiovascular events by influenza vaccination: an observational study.

ABSTRACT:

Aims

Previous studies show a reduced incidence of first myocardial infarction and stroke 1-3 months after influenza vaccination, but it is unclear how underlying cardiovascular risk impacts the association.

Methods and results

The study used linked Clinical Practice Research Datalink, Hospital Episode Statistics Admitted Patient Care and Office for National Statistics mortality data from England between 1 September 2008 and 31 August 2019. From the data, individuals aged 40-84 years with a first acute cardiovascular event and influenza vaccination occurring within 12 months of each September were selected. Using a self-controlled case series analysis, season-adjusted cardiovascular risk stratified incidence ratios (IRs) for cardiovascular events after vaccination compared wi

SUBMITTER: Davidson JA 

PROVIDER: S-EPMC9925273 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature