Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry.

ABSTRACT:

Aims

Cardiometabolic diseases (CMDs), including diabetes, heart disease, and stroke, are established risk factors for dementia, but their combined impact has been investigated only recently. This study aimed to examine the association between mid- and late-life cardiometabolic multimorbidity and dementia and explore the role of genetic background in this association.

Methods and results

Within the Swedish Twin Registry, 17 913 dementia-free individuals aged ≥60 were followed for 18 years. CMDs [including age of onset in mid (60) or late (≥60) life] and dementia were ascertained from medical records. Cardiometabolic multimorbidity was defined as having ≥2 CMDs. Cox regression was used to estimate the CMD-dementia association in (i) a classical cohort study design and (ii) a c

SUBMITTER: Dove A 

PROVIDER: S-EPMC9925275 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature