Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.

ABSTRACT: Aberrations in nuclear size and shape are commonly used to identify cancerous tissue. However, it remains unclear whether the disturbed nuclear structure directly contributes to the cancer pathology or is merely a consequence of other events occurring during tumorigenesis. Here, we show that highly invasive and proliferative breast cancer cells frequently exhibit Akt-driven lower expression of the nuclear envelope proteins lamin A/C, leading to increased nuclear deformability that permits enhanced cell migration through confined environments that mimic interstitial spaces encountered during metastasis. Importantly, increasing lamin A/C expression in highly invasive breast cancer cells reflected gene expression changes characteristic of human breast tumors with higher LMNA expression, and s

SUBMITTER: Bell ES 

PROVIDER: S-EPMC9925375 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature