Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation.

ABSTRACT: Epithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined action of multiciliated and secretory cells sustains the mucociliary escalator required for clearance of microbes and particles from the airways. Defects in components of mucociliary clearance or barrier integrity are associated with recurring infections and chronic inflammation. The timely and balanced differentiation of basal cells into mature epithelial cell subsets is therefore tightly controlled. While different growth factors regulating progenitor cell proliferation have been described, little is known about the role of metabolism in these regenerative processes. Here we show that basal cell differentiation correlates with a shif

SUBMITTER: Crotta S 

PROVIDER: S-EPMC9925445 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature