Phosphorylated chitosan accelerates dermal wound healing in diabetic wistar rats.

ABSTRACT: Phosphorylated chitosan (PC), a water-soluble derivative of chitosan possesses several biological and chemical properties suitable for diabetic wound healing. In the present study, we report the synthesis and diabetic wound healing capabilities of PC. Elemental analysis, FT-IR, ¹³C-NMR and ³¹P-NMR techniques were employed for the chemical characterization of PC. In vitro, antioxidant properties of PC were determined in terms of Fe³⁺ reducing, metal chelating, lipid peroxidation and superoxide scavenging ability. The wound healing potential of PC was assessed in diabetic excisional wound rat model. PC exhibited good water solubility, and in vitro antioxidant capacity. Wound contraction was higher in PC-treated wounds (91.11%) as compared to untreated wounds

SUBMITTER: Anushree U 

PROVIDER: S-EPMC9925528 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature