Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements.

ABSTRACT:

Background

Acute kidney injury (AKI) and augmented renal clearance (ARC), both alterations of the glomerular filtration rate (GFR), are prevalent in critically ill children and neonates. AKI and ARC prevalence estimates are based on estimation of GFR (eGFR) using serum creatinine (SCr), which is known to be inaccurate. We aimed to test our hypothesis that AKI prevalence will be higher and ARC prevalence will be lower in critically ill children when using iohexol-based measured GFR (mGFR), rather than using eGFR. Additionally, we aimed to investigate the performance of different SCr-based eGFR methods.

Methods

In this single-center prospective study, critically ill term-born neonates and children were included. mGFR was calculated using a plasma disappearance curve after pare

SUBMITTER: Smeets NJL 

PROVIDER: S-EPMC9925555 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature