Movement disorders in hereditary spastic paraplegia (HSP): a systematic review and individual participant data meta-analysis.

ABSTRACT:

Background

Hereditary spastic paraplegia (HSP) is a rare genetic disorder associated with mutations in > 80 loci designated SPG (SPastic parapleGia). The phenotypic spectrum of HSP can extend to include other neurologic features, including movement disorders. Our aim was to investigate genotype-phenotype associations in HSP with a focus on movement disorders.

Methods

We performed a systematic review and individual participant data (IPD)-level meta-analysis by retrieving publications from Medline/EMBASE/Web of Science on HSP with a SPG genotype. Studies were included only if individual-level information was accessible and at least one patient with a movement disorder was reported for that genotype. Out of 21,957 hits, 192 manuscripts with a total of 1413 HSP cases were eligib

SUBMITTER: Fereshtehnejad SM 

PROVIDER: S-EPMC9925593 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature