Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS.

ABSTRACT: B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and contribute to local tissue destruction. It remains unexplored, however, how infection and autoimmunity drive transcriptional phenotypes, repertoire features, and antibody functionality. Here, we profiled B cells from the CNS of murine models of intracranial (i.c.) viral infections and autoimmunity. We identified a population of clonally expanded, antibody-secreting cells (ASCs) that had undergone class-switch recombination and extensive somatic hypermutation following i.c. infection with attenuated lymphocytic choriomeningitis virus (rLCMV). Recombinant expression and ch

SUBMITTER: Agrafiotis A 

PROVIDER: S-EPMC9925600 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature