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Contemporary Pharmacotherapies for Nontuberculosis Mycobacterial Infections: A Narrative Review.


ABSTRACT: Nontuberculous mycobacteria (NTM) are a group of atypical bacteria that may cause a spectrum of clinical manifestations, including pulmonary, musculoskeletal, skin and soft tissue, and cardiac infections. Antimycobacterial medication regimens for NTM infections require multiple agents with prolonged treatment courses and are often associated with poor tolerance in patients and suboptimal clinical outcomes. This review summarizes NTM pharmacotherapy, including treatment concepts, preferred medication regimens according to NTM species and site of infection, and emerging treatment methods for difficult-to-treat species.

SUBMITTER: Johnson TM 

PROVIDER: S-EPMC9925655 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Contemporary Pharmacotherapies for Nontuberculosis Mycobacterial Infections: A Narrative Review.

Johnson Tanner M TM   Byrd Thomas F TF   Drummond Wendi K WK   Childs-Kean Lindsey M LM   Mahoney Monica V MV   Pearson Jeffrey C JC   Rivera Christina G CG  

Infectious diseases and therapy 20230107 2


Nontuberculous mycobacteria (NTM) are a group of atypical bacteria that may cause a spectrum of clinical manifestations, including pulmonary, musculoskeletal, skin and soft tissue, and cardiac infections. Antimycobacterial medication regimens for NTM infections require multiple agents with prolonged treatment courses and are often associated with poor tolerance in patients and suboptimal clinical outcomes. This review summarizes NTM pharmacotherapy, including treatment concepts, preferred medica  ...[more]

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