Light modulates Drosophila lifespan via perceptual systems independent of circadian rhythms.

ABSTRACT: Across taxa, sensory perception modulates aging in response to important ecological cues, including food, sex, and danger. The range of sensory cues involved, and their mechanism of action, are largely unknown. We therefore sought to better understand how one potential cue, that of light, impacts aging in Drosophila melanogaster. In accordance with recently published data, we found that flies lived significantly longer in constant darkness. Extended lifespan was not accompanied by behavioral changes that might indirectly slow aging such as activity, feeding, or fecundity, nor were circadian rhythms necessary for the effect. The lifespans of flies lacking eyes or photoreceptor neurons were unaffected by light kept at normal housing conditions, and transgenic activation of these same

SUBMITTER: Johnson JC 

PROVIDER: S-EPMC9925688 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature