Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice.

ABSTRACT: Frailty is the hallmark of aging that can be delayed with exercise. The present studies were initiated based on the hypothesis that long-term voluntary wheel running (VWR) in female mice from 12 to 18 or 22 months of age would have beneficial effects on the musculoskeletal system. Mice were separated into high (HBW) and low (LBW) body weight based on final body weights upon termination of experiments. Bone marrow fat was significantly higher in HBW than LBW under sedentary conditions, but not with VWR. HBW was more protective for soleus size and function than LBW under sedentary conditions, however VWR increased soleus size and function regardless of body weight. VWR plus HBW was more protective against muscle loss with aging. Similar effects of VWR plus HBW were observed with the extensor

SUBMITTER: Kitase Y 

PROVIDER: S-EPMC9925690 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature