Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity.

ABSTRACT: As the elderly population increases, chronic, age-associated diseases are challenging healthcare systems around the world. Nutrient limitation is well known to slow the aging process and improve health. Regrettably, practicing nutrient restriction to improve health is unachievable for most people. Alternatively, pharmacological strategies are being pursued including myriocin which increases lifespan in budding yeast. Myriocin impairs sphingolipid synthesis, resulting in lowered amino acid pools which promote entry into a quiescent, long-lived state. Here we present transcriptomic data during the first 6 hours of drug treatment that improves our mechanistic understanding of the cellular response to myriocin and reveals a new role for ubiquitin in longevity. Previously we found that the meth

SUBMITTER: Hepowit NL 

PROVIDER: S-EPMC9925692 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature