Ontology highlight
ABSTRACT:
SUBMITTER: Su B
PROVIDER: S-EPMC9925808 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Su Benyu B Lim David D Qi Chenyang C Zhang Zhongwei Z Wang Junxiao J Zhang Fengmei F Dong Chao C Feng Zhihui Z
Cell death & disease 20230213 2
Cell cycle checkpoint kinases play a pivotal role in protecting against replicative stress. In this study, valproic acid (VPA), a histone deacetylase inhibitor (HDACi), was found to promote breast cancer MCF-7 cells to traverse into G2/M phase for catastrophic injury by promoting PPP2R2A (the B-regulatory subunit of Phosphatase PP2A) to facilitate the dephosphorylation of Chk1 at Ser317 and Ser345. By contrast, VPA protected normal 16HBE cells from HU toxicity through decreasing PPP2R2A expressi ...[more]