Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies.

ABSTRACT: Background: Olanzapine is used to treat schizophrenia and bipolar disorder in women of childbearing age. Continuation of psychotropic medications throughout pregnancy and lactation is often required as cessation could be dangerous for both mother and child. However, there is a lack of information on the transfer of these drugs into the developing brain. Methods: Sprague Dawley rats at three developmental ages: embryonic day E19, postnatal day P4 and non-pregnant adult females were administered unlabelled or radiolabelled ( ³H) olanzapine (0.15 mg/kg) either as monotherapy or in combination with each of seven other common medications. Similar injections were administered to pregnant E19 females to investigate placental transfer. Olanzapine in plasma, cerebrospinal f

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9925881 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature