Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis.

ABSTRACT:

Background

The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON.

Objective

The objective of this study was to investigate the presence of subclinical ON abnormalities in pediatric-onset MS by means of magnetization transfer saturation and evaluate their association with other structural and functional parameters of visual pathway integrity.

Methods

Eleven youth living with pediatric-onset MS (ylPOMS) and no previous history of optic neuritis and 18 controls underwent standardized brain MRI, optical c

SUBMITTER: Longoni G 

PROVIDER: S-EPMC9925884 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature