Relationship between raltegravir trough plasma concentration and virologic response and the impact of therapeutic drug monitoring during pregnancy.

ABSTRACT:

Background

Limited data is available on raltegravir (RAL) pharmacokinetics during pregnancy and the value of therapeutic drug monitoring (TDM) in pregnancy is unknown. This study aims to describe RAL trough plasma concentrations (C_trough) during pregnancy and review the impact of RAL TDM on outcomes.

Methods

Women from the prospective mother-infant HIV cohort of Mother and Children's Infectious Diseases Center who received RAL during their pregnancy between 2011-2020 were included. TDM reports were reviewed and C_trough values estimated when possible, using historical RAL half-lives.

Results

We included 76 pregnant women of which 47 underwent TDM. We observed a significant association between virological response and C_trough (p-v

SUBMITTER: Carvalho S 

PROVIDER: S-EPMC9925909 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature