Antidepressant drug-drug-drug interactions associated with unintentional traumatic injury: Screening for signals in real-world data.

ABSTRACT: Antidepressants are associated with traumatic injury and are widely used with other medications. It remains unknown how drug-drug-drug interactions (3DIs) between antidepressants and two other drugs may impact potential injury risks associated with antidepressants. We aimed to generate hypotheses regarding antidepressant 3DI signals associated with elevated injury rates. Using 2000-2020 Optum's de-identified Clinformatics Data Mart, we performed a self-controlled case series study for each drug triad consisting of an antidepressant + codispensed drug (base-pair) with a candidate interacting medication (precipitant). We included persons aged greater than or equal to 16 years who (1) experienced an injury and (2) used a candidate precipitant, during base-pair therapy. We compared injury rate

SUBMITTER: Chen C 

PROVIDER: S-EPMC9926061 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature