Dataset of eyeblink conditioning in mice treated with the selective mGluR1 antagonist JNJ16259685.

ABSTRACT: Eyeblink conditioning is associated with motor learning, which requires the cerebellum and the brainstem. This article provides behavioral data on whether JNJ16259685, a selective metabotropic glutamate receptor type 1 (mGluR1) antagonist, affects eyeblink conditioning in wild-type mice (C57BL/6 J strain). The dataset contains four types of behavioral outputs pertinent to eyeblink conditioning. We used a t-test and an analysis of variance (ANOVA) to analyze the percentage of conditioned responses (CR%), peak CR latencies, onset CR latencies, and electromyography (EMG) amplitudes. The information obtained in this dataset adds to our knowledge of the molecular mechanisms underlying eyeblink conditioning and can prove beneficial for investigators studying the pharmacological effects of

SUBMITTER: Tohyama S 

PROVIDER: S-EPMC9926070 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature