Mitochondrial function, grip strength, and activity are related to recovery of mobility after a total knee arthroplasty.

ABSTRACT: Low muscle quality and a sedentary lifestyle are indicators for a slow recovery after a total knee arthroplasty (TKA). Mitochondrial function is an important part of muscle quality and a key driver of sarcopenia. However, it is not known whether it relates to recovery. In this pilot study, we monitored activity after TKA using a wrist mounted activity tracker and assessed the relation of mitochondrial function on the rate of recovery after TKA. Additionally, we compared the increase in activity as a way to measure recovery to traditional outcome measures. Patients were studied 2 weeks before TKA and up to 6 months after. Activity was monitored continuously. Baseline mitochondrial function (citrate synthase and complex [CP] 1-5 abundance of the electron transport chain) was determined on mu

SUBMITTER: van Diemen MPJ 

PROVIDER: S-EPMC9926084 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature