Modeling congenital brain malformations with brain organoids: a narrative review.

ABSTRACT:

Background and objective

During embryonic development, the dysregulation of the proliferation and differentiation of neuronal progenitors triggers congenital brain malformations. These malformations are common causes of morbidity and mortality in patients younger than 2 years old. Animal models have provided considerable insights into the etiology of diseases that cause congenital brain malformations. However, the interspecies differences in brain structure limit the ability to transfer these insights directly to studies of humans. In recent years, brain organoids generated from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) using a 3-dimensional (3D) culture system have been used to resemble the structure and function of a developing human brai

SUBMITTER: Ji XS 

PROVIDER: S-EPMC9926131 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature