DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K⁺ channels.

ABSTRACT: The human ether-a-go-go-related gene (hERG) K⁺ channel conducts a rapidly activating delayed rectifier K⁺ current (I_Kr), which is essential for normal electrical activity of the heart. Precise regulation of hERG channel biogenesis is critical for serving its physiological functions, and deviations from the regulation result in human diseases. However, the mechanism underlying the precise regulation of hERG channel biogenesis remains elusive. Here, by using forward genetic screen, we found that PATR-1, the Caenorhabditis elegans homolog of the yeast DNA topoisomerase 2-associated protein PAT1, is a critical regulator for the biogenesis of UNC-103, the ERG K⁺ channel in C. elegans. A loss-of-function mutation in patr-1 down-reg

SUBMITTER: Yao L 

PROVIDER: S-EPMC9926248 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature