Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae.

ABSTRACT: Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Saccharomyces cerevisiae Pho regulon. When external inorganic phosphate (P_i) concentration is low, the Pho regulon activates, expressing genes that scavenge external and internal P_i. However, the precise mechanism controlling this regulon remains elusive. We conducted a systems analysis of the Pho regulon on the single-cell level under well-controlled environmental conditions. This analysis identified a robust, perfectly adapted Pho regulon state in intermediate P_i conditions, and we identified an intermediate nuclear

SUBMITTER: Ming Yip H 

PROVIDER: S-EPMC9926285 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature