Bacteriophages playing nice: Lysogenic bacteriophage replication stable in the human gut microbiota.

ABSTRACT: Bacteriophages, viruses specific to bacteria, coexist with their bacterial hosts with limited diversity fluctuations in the guts of healthy individuals where they replicate mostly via lysogenic replication. This favors 'piggy-back-the-winner' over 'kill-the-winner' dynamics which are driven by lytic bacteriophage replication. Revisiting the deep-viral sequencing data of a healthy individual sampled over 2.4 years, we explore how these dynamics occur. Prophages found in assembled bacterial metagenomes were also found extra-cellularly, as induced phage particles (iPPs), likely derived from prophage activation. These iPPs were diverse and continually present in low abundance, relative to the highly abundant but less diverse lytic phage population. The continuous detection of low levels of iPP

SUBMITTER: Sutcliffe SG 

PROVIDER: S-EPMC9926308 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature