HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways.

ABSTRACT: Cells respond to multiple signals from the environment simultaneously, which often creates crosstalk between pathways affecting the capacity to adapt to the changing environment. Chaperones are an important component in the cellular integration of multiple responses to environmental signals, often implicated in negative feedback and inactivation mechanisms. These mechanisms include the stabilization of steroid hormone nuclear receptors in the cytoplasm in the absence of their ligand. Here, we show using immunofluorescence, chromatin immunoprecipitation, and nascent transcripts production that the heat shock protein 70 (HSP70) chaperone plays a central role in a new crosstalk mechanism between the steroid and heat shock response pathways. HSP70-dependent feedback mechanisms are required to

SUBMITTER: Silveira MAD 

PROVIDER: S-EPMC9926311 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature