Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle.

ABSTRACT:

Background

Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfusion. Myofibers and microvessels regenerate from satellite cells and from surviving microvessel fragments, respectively, to restore intact muscle. Established models of injury have used myotoxins and physical trauma to demonstrate the concurrence of myogenesis and angiogenesis during regeneration. In these models, efferocytosis removes cellular debris while basal laminae persist to provide guidance during myofiber and microvessel regeneration. It is unknown whether the spatiotemporal coupling between myofiber and microvascular regeneration persists when muscle tissue is completely removed and local guidance cues are lost.

Methods

To test whethe

SUBMITTER: Jacobsen NL 

PROVIDER: S-EPMC9926536 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature