Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers.

ABSTRACT:

Background

Recently in Japan, six workers at a chemical plant that manufactures resins developed interstitial lung diseases after being involved in loading and packing cross-linked water-soluble acrylic acid polymers (CWAAPs). The present study focused on assessing lung damage in rats caused by workplace-relevant inhalation exposure to CWAAP and investigated the molecular and cellular mechanisms involved in lung lesion development.

Methods

Using a whole-body inhalation exposure system, male F344 rats were exposed once to 40 or 100 mg/m³ of CWAAP-A for 4 h or to 15 or 40 mg/m³ of CWAAP-A for 4 h per day once per week for 2 months (9 exposures). In a separate set of experiments, male F344 rats were administered 1 mg/kg CWAAP-A or CWAAP-B by intratracheal

SUBMITTER: Yamano S 

PROVIDER: S-EPMC9926550 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature