PEEP application during mechanical ventilation contributes to fibrosis in the diaphragm.

ABSTRACT:

Background

Positive end-expiratory airway pressure (PEEP) is a potent component of management for patients receiving mechanical ventilation (MV). However, PEEP may cause the development of diaphragm remodeling, making it difficult for patients to be weaned from MV. The current study aimed to explore the role of PEEP in VIDD.

Methods

Eighteen adult male New Zealand rabbits were divided into three groups at random: nonventilated animals (the CON group), animals with volume-assist/control mode without/ with PEEP 8 cmH₂O (the MV group/ the MV + PEEP group) for 48 h with mechanical ventilation. Ventilator parameters and diaphragm were collected during the experiment for further analysis.

Results

There was no difference among the three groups in arterial blood ga

SUBMITTER: Qian X 

PROVIDER: S-EPMC9926671 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature