CXCL10 is a prognostic marker for pancreatic adenocarcinoma and tumor microenvironment remodeling.

ABSTRACT:

Background

The tumor microenvironment (TME) plays a crucial role in the progression of pancreatic adenocarcinoma (PAAD). However, challenges remain regarding the role played by TME associated genes in the prognosis of PAAD.

Methods

The scores of tumor infiltrating immune cells (TICs), the immune and stroma scores of 182 PAAD patients in the Cancer Genome Atlas (TCGA) database were determined using CIBERSORT and ESTIMATE calculations. The final genes were identified by protein-protein interaction (PPI) networks and univariate Cox regression of differentially expressed genes. Finally, the correlation between gene expression and TCGA and clinical characteristics of patients in local hospital database was discussed. Gene set enrichment analysis (GSEA), the association between CX

SUBMITTER: Nie Y 

PROVIDER: S-EPMC9926744 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature