Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis.

ABSTRACT:

Objective

The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle researchers.

Methods

Five databases including the Cochrane Library, PubMed, Scopus, Web of Science, and Embase were searched for eligible studies until April 2022. The quality of the selected studies was assessed by SYRCLE's risk of bias (RoB) tool, and the random-effects model was used to calculate the overall effect sizes of weighted mean differences (WMD).

Results

Ten studies met the inclusion criteria. Results showed that nanoparticles were effective in reducing uric acid levels (WMD: -4.91; 95% confidence interval (CI):

SUBMITTER: Zhu R 

PROVIDER: S-EPMC9926759 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature