Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395.

ABSTRACT:

Background

Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well as convergent representatives. It is known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, and 307 drive their global spread. ST395, which was first reported in the context of a carbapenemase-associated outbreak in France in 2010, is a less well-characterized, yet emerging clonal lineage.

Methods

We computationally analyzed a large collection of K. pneumoniae ST395 genomes (n = 297) both sequenced in this study and reported previously. By applying multiple bioinformatics tools, we investigated the core-genome phylogeny and evolution of S

SUBMITTER: Shaidullina ER 

PROVIDER: S-EPMC9926764 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature