Epigenome-wide analysis of aging effects on liver regeneration.

ABSTRACT:

Background

Aging is known to exert an effect on liver regeneration, with the ability of liver to regenerate displaying a significant decline over time. Liver physiological parameters such as liver volume, blood flow, and metabolism, as well as the ability to regenerate after injury have all been shown to decrease at old age in humans and model systems, with a number of molecular mechanisms proposed to be involved, including DNA methylation-dependent genome remodeling. To address how changes in DNA methylation mediate the adverse aging effect on liver regeneration, we searched for differentially methylated genomic regions (DMRs) in mouse livers co-regulated by aging and regeneration and determined their associated genes and enriched pathways.

Results

DMRs were identified usin

SUBMITTER: Wang J 

PROVIDER: S-EPMC9926786 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature