Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The most commonly acknowledged non-scarring alopecia are androgenetic alopecia (AGA) and alopecia areata (AA). Previous studies have revealed various risk factors associated with alopecia. However, the relationship between leukocyte telomere length (LTL) and non-scarring alopecia remains unclear.

Methods

A two-sample Mendelian randomization (MR) analysis was performed to evaluate the causality between genetically predicted LTL and the risk of non-scarring alopecia. MR analyses were performed using the inverse variance-weighted (IVW) method and complemented with other MR methods.

Results

The summary statistics of the genome-wide association studies (GWAS) for AGA and AA were obtained from the FinnGen biobank, which included 119,185 and 211,428 individuals, r

SUBMITTER: Li Y 

PROVIDER: S-EPMC9926966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature