Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture.

ABSTRACT:

Key points

The amount of fibrotic material in dystrophic mouse muscles relates to contractile function, but not passive function. Collagen fibres in skeletal muscle are associated with increased passive muscle stiffness in fibrotic muscles. The alignment of collagen is independently associated with passive stiffness in dystrophic skeletal muscles. These outcomes demonstrate that collagen architecture rather than collagen content should be a target of anti-fibrotic therapies to treat muscle stiffness.

Abstract

Fibrosis is prominent in many skeletal muscle pathologies including dystrophies, neurological disorders, cachexia, chronic kidney disease, sarcopenia and metabolic disorders. Fibrosis in muscle is associated with decreased contractile forces and increased passive stiffn

SUBMITTER: Brashear SE 

PROVIDER: S-EPMC9926974 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature