Decreased granzyme-B expression in CD11c⁺CD8⁺ T cells associated with disease progression in patients with HBV-related hepatocellular carcinoma.

ABSTRACT:

Introduction

CD11c⁺CD8⁺ T cells are an unconventional CD8⁺ T cell subset that exerts antiviral activity in infectious diseases. However, its characteristics in hepatocellular carcinoma (HCC) have not been elucidated.

Methods

Twenty-six patients with hepatitis B virus (HBV)-related HCC and 25 healthy controls (HC) were enrolled. The frequency and phenotype of CD11c⁺CD8⁺ T cells in peripheral blood and tumors in situ were detected by flow cytometry and immunohistochemistry.

Results

Both the HCC group and HC group had similar frequency and phenotype characteristics of CD11c⁺CD8⁺ T cells in the periphery. CD11c⁺CD8⁺ T cells were mainly composed of effector T cells, most of w

SUBMITTER: Gao L 

PROVIDER: S-EPMC9927008 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature