Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.

ABSTRACT:

Background

Modern societies face infertility as a global challenge. There are certain environmental conditions and disorders that damage testicular tissue and may cause male infertility. Melatonin, as a potential antioxidant, may protect testicular tissue. Therefore, we conducted this systematic review and meta-analysis to evaluate the effects of melatonin in animal models against physical, heat, and ischemic damage to the testicular tissue.

Methods

PubMed, Scopus, and Web of Science were systematically searched to identify animal trials evaluating the protective effect of melatonin therapy on rodent testicular tissue when it is exposed to physical, thermal, ischemic, or hypobaric oxygen stress. Random-effect modeling was used to estimate the standardized mean difference and

SUBMITTER: Dehdari Ebrahimi N 

PROVIDER: S-EPMC9927015 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature