MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.

ABSTRACT: Obesity induces a chronic inflammatory state associated with changes in adipose tissue macrophages (ATMs). Macrophage scavenger receptor 1 (MSR1) has been implicated in the regulation of adipose tissue inflammation and diabetes pathogenesis; however, reports have been mixed on the contribution of MSR1 in obesity and glucose intolerance. We observed increased MSR1 expression in VAT of obese diabetic individuals compared to non-diabetic and single nuclear RNA sequencing identified macrophage-specific expression of MSR1 in human adipose tissue. We examined male Msr1^-/- (Msr1KO) and WT controls and observed protection from obesity and AT inflammation in non-littermate Msr1KO mice. We then evaluated obese littermate Msr1^+/- (Msr1HET) and Msr1KO mice. Both Msr1KO mice and M

SUBMITTER: Nance SA 

PROVIDER: S-EPMC9927046 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature