Fusion plasmid enhanced the endemic extensively drug resistant Klebsiella pneumoniae clone ST147 harbored bla_OXA-48 to acquire the hypervirulence and cause fatal infection.

ABSTRACT:

Background

Klebsiella Pneumoniae (Kp) sequence type (ST) 147 has emerged globally and spread rapidly, particularly the extensively drug resistant (XDR) isolates. However, the infections caused by this subtype is rare reported in China for now. The clinical, microbiological and genomic characteristics are unclear.

Methods

A systemic retrospective study was conducted in a Chinese tertiary hospital. Clinical information of the infection cases was collected, and whole-genome sequencing and phenotypic experiments were performed on the ST147 isolates. The resistance and virulence genes were identified, and the plasmids harboring these genes were further studied.

Results

Six ST147 isolates from six patients among 720 available clincial Kp isolates were detected. Notably, two

SUBMITTER: Liu C 

PROVIDER: S-EPMC9927049 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature