Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus.

ABSTRACT: The reprogramming of cellular metabolism of immune cells is an essential process in the regulation of antifungal immune responses. In particular, glucose metabolism has been shown to be required for protective immunity against infection with Aspergillus fumigatus. However, given the intricate cross talk between multiple metabolic networks and signals, it is likely that cellular metabolic pathways other than glycolysis are also relevant during fungal infection. In this study, we demonstrate that glutamine metabolism is required for the activation of macrophage effector functions against A. fumigatus. Glutamine metabolism was found to be upregulated early after fungal infection and glutamine depletion or the pharmacological inhibition of enzymes involved in its metabolism impaired phagocytos

SUBMITTER: Antunes D 

PROVIDER: S-EPMC9927096 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature