Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia.

ABSTRACT:

Purpose

This study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia (AML) by establishing a predictive risk classification model.

Method

A total of 214 AML patients who were pathologically diagnosed and treated with standard induction chemotherapy at Sun Yat-Sen University Cancer Center were included. The patients were randomly divided into the training (n = 107) and validation (n=107) cohorts. Univariate and multivariate Cox analyses were used to assess the value of triglyceride (TG), Apolipoprotein B (Apo B), Apo Apolipoprotein A-I (Apo A-I), cholesterol (CHO), and high-density lipoprotein (HDL) as prognostic factors for AML.

Results

After a series of data analyses, a five-factor model was established to divide

SUBMITTER: Bai S 

PROVIDER: S-EPMC9927215 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature